Livial® (tibolone), an agent used to reduce menopausal symptoms as well as bone loss, significantly reduces the risk of breast cancer and prevents bone loss and fractures; however, it doubles the risk of stroke among postmenopausal women. These results were recently published in the New England Journal of Medicine. Dec 11, · The Million Women Study identified a significantly increased risk of having breast cancer diagnosed in tibolone users (relative risk [RR] 1·5 .
Tibolone has been shown to regulate estrogenic activity in several tissue types by influencing the availability of estrogenic compounds for the estradiol receptor in a selective manner [A]. Additionally, tibolone modulates cellular homeostasis in the breast by preventing breast tissue proliferation and stimulating cell apoptosis. Jul 15, · Breast safety studies in the 7,dimethylbenz (a)anthracene model have shown that tibolone is highly effective in reducing tumor growth in mice (10). In addition, tibolone inhibits the sulfatase enzyme and promotes apoptosis in normal as well as breast cancer cells, thus suggesting a local antiestrogenic effect (11).Cited by:
Oct 01, · Tibolone is an antiproliferative and proapoptotic drug that induces differentiation of normal breast sissysexwife.xyz by: 8. Breast tissue of monkeys is not found to be stimulated after tibolone administration, as occurs with estrogen plus progesterone used in combination. This is explained by the fact that tibolone and its metabolites inhibit sulphatase and 17 beta-hydroxysteroid dehydrogenase (HSD) type I and stimulate sulphotransferase and 17 beta-HSD type II.
Tibolone. The first “bleed-free” HRT contained a synthetic hormone known as Tibolone which, when taken every day, had the combined effects of oestrogen, progestogen and testosterone. Tibolone relieves menopausal symptoms, prevents bone loss, and may improve interest in sex. tibolone use was associated with a reduction in the risk of invasive breast cancer to a degree that was similar to that observed for treatment with tamoxifen or raloxifene unclear why the results of this trial contrast with the data from the Million Women Study.
• Tibolone prevents bone loss and reduces spinal fractures . • One uncontrolled English study has suggested that tibolone increases breast cancer risk but better quality placebo controlled randomised trials do not show that breast cancer rates in healthy women are changed by tibolone . • Tibolone does not increase breast density . Jun 28, · Evidence with respect to breast cancer risk in association with tibolone is inconclusive. The Million Women Study (MWS) has identified a significant increase in the risk of breast cancer in association with use of the mg dose.